Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An "ab initio" Study

被引：14
作者：
Curcio, Manuela [1 ,2 ]
Cirillo, Giuseppe [1 ,2 ]
Parisi, Ortensia Ilaria [1 ,2 ]
Iemma, Francesca [1 ]
Spizzirri, Umile Gianfranco [1 ]
Altimari, Ilaria [1 ]
Picci, Nevio [1 ]
Puoci, Francesco [1 ]
机构：
[1] Univ Calabria, Dipartimento Sci Farmaceut, Edificio Polifunz, I-87036 Arcavacata Di Rende, CS, Italy
[2] Univ Calabria, Macrofarm Srl, I-87036 Arcavacata Di Rende, CS, Italy
来源：
JOURNAL OF FUNCTIONAL BIOMATERIALS | 2011年 / 2卷 / 01期
关键词：
poly(2-hydroxyethyl methacrylate; quercetin; ocular tolerance; polymeric antioxidant;
D O I：
10.3390/jfb2010001
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A novel polymeric material with antioxidant properties and suitable for ophthalmic application was synthesized by free radical grafting reaction between 2-hydroxyethyl methacrylate and quercetin. The presence of quercetin in the polymeric chain was confirmed by FT-IR and UV-Vis analyses, while an estimation of the amount of quercetin bound per gram of polymer was obtained by the Folin-Ciocalteu assay. The conjugate shows high biocompatibility (HET-CAM assay) and antioxidant and anti-inflammatory properties which were extensively investigated by specific in vitro tests.
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页码：1 / 17
页数：17
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