CHARACTERIZATION OF TYPE-I RECEPTORS FOR TRANSFORMING GROWTH-FACTOR-BETA AND ACTIVIN

被引：518
作者：
TENDIJKE, P
YAMASHITA, H
ICHIJO, H
FRANZEN, P
LAIHO, M
MIYAZONO, K
HELDIN, CH
机构：
[1] LUDWIG INST CANC RES,BOX 595 BIOMED CTR,S-75124 UPPSALA,SWEDEN
[2] UNIV HELSINKI,DEPT VIROL,SF-00014 HELSINKI,FINLAND
来源：
SCIENCE | 1994年 / 264卷 / 5155期
关键词：
D O I：
10.1126/science.8140412
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Transforming growth factor-beta (TGF-beta) and activin exert their effects by binding to heteromeric complexes of type I and type II receptors. The type II receptors for TGF-beta and activin are transmembrane serine-threonine kinases; a series of related receptors, denoted activin receptor-like kinase (ALK) 1 to 5, have recently been identified, and ALK-6 is described here. ALK-5 has been shown to be a functional TGF-beta type I receptor. A systematic analysis revealed that most ALKs formed heteromeric complexes with the type II receptors for TGF-beta and activin after overexpression in COS cells; however, among the six ALKs, only ALK-5 was a functional TGF-beta type I receptor for activation of plasminogen activator inhibitor-1, and only ALK-2 and ALK-4 bound activin with high affinity.
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页码：101 / 104
页数：4
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