TRANSPLANTATION OF AUTOLOGOUS PERIPHERAL-BLOOD STEM-CELLS MOBILIZED USING GM-CSF FOR ACUTE-LEUKEMIA WITH MYELOFIBROSIS

被引：5
作者：
MEHTA, J
POWLES, RL
SHEPHERD, V
DAINTON, M
TRELEAVEN, J
机构：
[1] Leukaemia Unit, Royal Marsden Hospital, Sutton, Surrey SM2 SPT, Downs Road
来源：
LEUKEMIA & LYMPHOMA | 1993年 / 11卷 / 1-2期
关键词：
ACUTE LEUKEMIA; AUTOLOGOUS BLOOD STEM CELL TRANSPLANTATION; GM-CSF; MYELOFIBROSIS;
D O I：
10.3109/10428199309054746
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A patient with acute mixed lineage leukemia had marked marrow fibrosis at presentation. The fibrosis persisted despite achievement of complete remission. Because the marrow was inaspirable, granulocyte-monocyte colony-stimulating factor (GM-CSF) was used to mobilize stem cells into the peripheral blood which were used for autologous transplantation. Myeloid engraftment was rapid. The extent of the fibrosis decreased after transplantation. GM-CSF-mobilized peripheral blood stem cells may be used for autologous transplantation in patients with fibrotic marrows who are not candidates for allografting.
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收藏
页码：157 / 158
页数：2
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