A MINUTE DELETION OF THE Y-CHROMOSOME IN MEN WITH AZOOSPERMIA

被引：71
|
作者：
NAGAFUCHI, S
NAMIKI, M
NAKAHORI, Y
KONDOH, N
OKUYAMA, A
NAKAGOME, Y
机构：
[1] UNIV TOKYO,SCH INT HLTH,DEPT HUMAN GENET,7-3-1 HONGO,BUNKYO KU,TOKYO 113,JAPAN
[2] NATL CHILDRENS MED RES CTR,DEPT CONGENITAL ABNORMAL RES,TOKYO,JAPAN
[3] OSAKA UNIV,SCH MED,DEPT UROL,OSAKA,JAPAN
来源：
JOURNAL OF UROLOGY | 1993年 / 150卷 / 04期
关键词：
OLIGOSPERMIA; Y-CHROMOSOME; CHROMOSOME DELETION; DNA;
D O I：
10.1016/S0022-5347(17)35712-9
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
We analyzed deoxyribonucleic acid from 50 Japanese men with azoospermia whose Y chromosomes were cytogenetically normal. A total of 26 loci was examined in each patient. Of these patients 6 had small interstitial deletions, each of which was located within the distal part of Yq11. Five of these 6 patients lacked the same 2 loci, DYS7C and DYS1, while 1 patient had a larger deletion including DYS7C but not DYS1. More than 10% of all men with azoospermia of unknown origin may have minute interstitial deletions of the Y chromosome surrounding the DYS7C locus. The proximal part of this zone presumably encompasses the gene deletion that causes azoospermia.
引用
收藏
页码：1155 / 1157
页数：3
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