EFFECT OF NALOXONE-PRECIPITATED MORPHINE-WITHDRAWAL ON NORADRENALINE RELEASE IN RAT HIPPOCAMPUS INVIVO

被引：70

作者：

DONE, C ^{[1
]}

SILVERSTONE, P ^{[1
]}

SHARP, T ^{[1
]}

机构：

[1] UNIV OXFORD,RADCLIFFE INFIRM,DEPT CLIN PHARMACOL,OXFORD OX2 6HE,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 215卷 / 2-3期

基金：

英国医学研究理事会;

关键词：

MICRODIALYSIS; NORADRENALINE; HIPPOCAMPUS; MORPHINE WITHDRAWAL; CLONIDINE;

D O I：

10.1016/0014-2999(92)90052-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Here we investigated the effect of naloxone-precipitated morphine withdrawal on the release of noradrenaline in hippocampus of the anaesthetised rat. Naloxone (1 mg/kg i.p.) injected 3 and 24 h, but not 3 weeks, after eight daily injections of morphine, induced an immediate increase in hippocampal noradrenaline release. This striking effect of naloxone was markedly attenuated by pretreatment with clonidine (0.1 mg/kg s.c.). These findings provide direct evidence for a marked release of noradrenaline in hippocampus during opiate withdrawal in vivo.

引用

页码：333 / 336

页数：4

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