COMPUTATIONAL APPROACH TO UNDERSTANDING AUTISM SPECTRUM DISORDERS

被引：14

作者：

Duch, Wlodzislaw ^{[1
]}

Nowak, Wieslaw ^{[2
]}

Meller, Jaroslaw ^{[1
]}

Osinski, Grzegorz ^{[1
]}

Dobosz, Krzysztof ^{[1
]}

Mikolajewski, Dariusz ^{[1
]}

Wojcik, Grzegorz M. ^{[3
]}

机构：

[1] Nicolaus Copernicus Univ, Dept Informat, Ul Grudziadzka 5, PL-87100 Torun, Poland

[2] Nicolaus Copernicus Univ, Inst Phys, PL-87100 Torun, Poland

[3] Marie Curie Sklodowska Univ, Inst Comp Sci, PL-20031 Lublin, Poland

来源：

COMPUTER SCIENCE-AGH | 2012年 / 13卷 / 02期

关键词：

computational neuroscience; neural networks; autism; Autism Spectrum Disorders; ASD;

D O I：

10.7494/csci.2012.13.2.47

中图分类号：

TP301 [理论、方法];

学科分类号：

081202 ;

摘要：

Every year the prevalence of Autism Spectrum of Disorders (ASD) is rising. Is there a unifying mechanism of various ASD cases at the genetic, molecular, cellular or systems level? The hypothesis advanced in this paper is focused on neural dysfunctions that lead to problems with attention in autistic people. Simulations of attractor neural networks performing cognitive functions help to assess system long-term neurodynamics. The Fuzzy Symbolic Dynamics (FSD) technique is used for the visualization of attractors in the semantic layer of the neural model of reading. Large-scale simulations of brain structures characterized by a high order of complexity requires enormous computational power, especially if biologically motivated neuron models are used to investigate the influence of cellular structure dysfunctions on the network dynamics. Such simulations have to be implemented on computer clusters in a grid-based architectures.

引用

页码：47 / 61

页数：15

共 26 条

[1]

[Anonymous], 2009, THEORETICAL NEUROCYB

[2] Autism: The Empathizing-Systemizing (E-S) Theory [J].

Baron-Cohen, Simon .

YEAR IN COGNITIVE NEUROSCIENCE 2009, 2009, 1156 :68-80

[3] Prevalence of autism-spectrum conditions: UK school-based population study [J].

Baron-Cohen, Simon ;

Scott, Fiona J. ;

Allison, Carrie ;

Williams, Joanna ;

Bolton, Patrick ;

Matthews, Fiona E. ;

Brayne, Carol .

BRITISH JOURNAL OF PSYCHIATRY, 2009, 194 (06) :500-509

[4] PHENOMICS: THE SYSTEMATIC STUDY OF PHENOTYPES ON A GENOME-WIDE SCALE [J].

Bilder, R. M. ;

Sabb, F. W. ;

Cannon, T. D. ;

London, E. D. ;

Jentsch, J. D. ;

Parker, D. Stott ;

Poldrack, R. A. ;

Evans, C. ;

Freimer, N. B. .

NEUROSCIENCE, 2009, 164 (01) :30-42

[5]

Bilder Robert M, 2009, Cogn Neuropsychiatry, V14, P419, DOI 10.1080/13546800902787180

[6]

Bower James M, 1998, BOOK GENESIS EXPLORI, DOI [DOI 10.1007/978-1-4612-1634-6, 10.1007/978-1-4612-1634-6]

[7] Default-mode brain dysfunction in mental disorders: A systematic review [J].

Broyd, Samantha J. ;

Demanuele, Charmaine ;

Debener, Stefan ;

Helps, Suzannah K. ;

James, Christopher J. ;

Sonuga-Barke, Edmund J. S. .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2009, 33 (03) :279-296

[8] The neuropathology of autism [J].

Casanova, Manuel F. .

BRAIN PATHOLOGY, 2007, 17 (04) :422-433

[9] Understanding neurodynamical systems via Fuzzy Symbolic Dynamics [J].

Dobosz, Krzysztof ;

Duch, Wiodzislaw .

NEURAL NETWORKS, 2010, 23 (04) :487-496

[10] Visualization for understanding of neurodynamical systems [J].

Duch, Wlodzislaw ;

Dobosz, Krzysztof .

COGNITIVE NEURODYNAMICS, 2011, 5 (02) :145-160

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