BOOSTER VACCINATION AGAINST DIPHTHERIA AND TETANUS IN MAN - COMPARISON OF CALCIUM-PHOSPHATE AND ALUMINUM HYDROXIDE AS ADJUVANTS .2.

被引：27
作者：
AGGERBECK, H [1 ]
FENGER, C [1 ]
HERON, I [1 ]
机构：
[1] HOVELTE KASERNE,DK-3460 BIRKEROD,DENMARK
来源：
VACCINE | 1995年 / 13卷 / 14期
关键词：
VACCINATION; DIPHTHERIA; TETANUS; ADJUVANT; CALCIUM PHOSPHATE; ALUMINUM HYDROXIDE;
D O I：
10.1016/0264-410X(94)00082-X
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Diphtheria and tetanus antibody levels were measured before and four weeks after booster vaccination of 313 Danish military recruits participating in a clinical trial to compare aluminium hydroxide and calcium phosphate as adjuvants in diphtheria-tetanus vaccines (DT). Twenty-eight percent of the men had a diphtheria pre-vaccination content below a protective level of 0.01 IU ml(-1). The calcium phosphate adsorbed vaccine showed the highest efficacy for both antigens. Adverse reactions were rare bur more frequent in the calcium group than in the aluminium group. No correlation was found between pre- or post-vaccination levels and adverse reactions and both vaccines gave rise to specific IgE formation. The results show that calcium phosphate is more effective but not a safer alternative to aluminium hydroxide when compared in vaccines containing 1.0 mg ml(-1) of Ca or of Al.
引用
收藏
页码：1366 / 1374
页数：9
相关论文
共 32 条
[11]   PERSISTENT SUBCUTANEOUS NODULES IN CHILDREN HYPOSENSITIZED WITH ALUMINUM-CONTAINING ALLERGEN EXTRACTS [J].
FROST, L ;
JOHANSEN, P ;
PEDERSEN, S ;
VEIEN, N ;
OSTERGAARD, PA ;
NIELSEN, MH .
ALLERGY, 1985, 40 (05) :368-372
[12]   ADVERSE REACTIONS AFTER INJECTION OF ADSORBED DIPHTHERIA PERTUSSIS TETANUS (DPT) VACCINE ARE NOT DUE ONLY TO PERTUSSIS ORGANISMS OR PERTUSSIS COMPONENTS IN THE VACCINE [J].
GUPTA, RK ;
RELYVELD, EH .
VACCINE, 1991, 9 (10) :699-702
[13]   ADJUVANTS - A BALANCE BETWEEN TOXICITY AND ADJUVANTICITY [J].
GUPTA, RK ;
RELYVELD, EH ;
LINDBLAD, EB ;
BIZZINI, B ;
BENEFRAIM, S ;
GUPTA, CK .
VACCINE, 1993, 11 (03) :293-306
[14]  
Ipsen Johannes, 1942, ZEITSCHR IMMUNITATSFORSCH, V102, P347
[15]  
KISHIMOT.T, 1973, J IMMUNOL, V111, P1
[16]  
MACLENNAN R, 1965, B WORLD HEALTH ORGAN, V32, P683
[17]   THE ROLE OF ALUMINUM FOR ADVERSE REACTIONS AND IMMUNOGENICITY OF DIPHTHERIA-TETANUS BOOSTER VACCINE [J].
MARK, A ;
GRANSTROM, M .
ACTA PAEDIATRICA, 1994, 83 (02) :159-163
[18]  
MATIC D, 1966, B WORLD HEALTH ORGAN, V34, P21
[19]  
NAGEL J, 1977, J IMMUNOL, V118, P334
[20]   IGE PRODUCTION BY NORMAL HUMAN-LYMPHOCYTES IS INDUCED BY INTERLEUKIN-4 AND SUPPRESSED BY INTERFERON-GAMMA AND INTERFERON-ALPHA AND PROSTAGLANDIN-E2 [J].
PENE, J ;
ROUSSET, F ;
BRIERE, F ;
CHRETIEN, I ;
BONNEFOY, JY ;
SPITS, H ;
YOKOTA, T ;
ARAI, N ;
ARAI, KI ;
BANCHEREAU, J ;
DEVRIES, JE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (18) :6880-6884
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