MULTIPLE G-PROTEIN-COUPLED PATHWAYS INHIBIT N-TYPE CA CHANNELS OF NEURONS

被引：27
|
作者：
HILLE, B
BEECH, DJ
BERNHEIM, L
MATHIE, A
SHAPIRO, MS
WOLLMUTH, LP
机构：
[1] UNIV LEEDS,DEPT PHARMACOL,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND
[2] UNIV GENEVA,CTR MED,ECOLE MED,DEPT PHYSIOL,CH-1211 GENEVA 4,SWITZERLAND
[3] ROYAL FREE HOSP,SCH MED,DEPT PHARMACOL,LONDON NW3 2PF,ENGLAND
[4] MAX PLANCK INST MED RES,ZELLPHYSIOL ABT,D-69028 HEIDELBERG,GERMANY
来源：
LIFE SCIENCES | 1995年 / 56卷 / 11-12期
关键词：
SYMPATHETIC GANGLION; PERTUSSIS TOXIN; PIRENZEPINE; HIMBACINE; MUSCARINIC RECEPTOR;
D O I：
10.1016/0024-3205(95)00038-8
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Muscarinic receptors depress Ca2+ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists.
引用
收藏
页码：989 / 992
页数：4
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