MULTIPLE G-PROTEIN-COUPLED PATHWAYS INHIBIT N-TYPE CA CHANNELS OF NEURONS

被引：27
作者：
HILLE, B
BEECH, DJ
BERNHEIM, L
MATHIE, A
SHAPIRO, MS
WOLLMUTH, LP
机构：
[1] UNIV LEEDS,DEPT PHARMACOL,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND
[2] UNIV GENEVA,CTR MED,ECOLE MED,DEPT PHYSIOL,CH-1211 GENEVA 4,SWITZERLAND
[3] ROYAL FREE HOSP,SCH MED,DEPT PHARMACOL,LONDON NW3 2PF,ENGLAND
[4] MAX PLANCK INST MED RES,ZELLPHYSIOL ABT,D-69028 HEIDELBERG,GERMANY
来源：
LIFE SCIENCES | 1995年 / 56卷 / 11-12期
关键词：
SYMPATHETIC GANGLION; PERTUSSIS TOXIN; PIRENZEPINE; HIMBACINE; MUSCARINIC RECEPTOR;
D O I：
10.1016/0024-3205(95)00038-8
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Muscarinic receptors depress Ca2+ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists.
引用
收藏
页码：989 / 992
页数：4
相关论文
共 34 条
[1]   PHARMACOLOGICAL INHIBITION OF THE M-CURRENT [J].
ADAMS, PR ;
BROWN, DA ;
CONSTANTI, A .
JOURNAL OF PHYSIOLOGY-LONDON, 1982, 332 (NOV) :223-262
[2]   MODULATION OF VERTEBRATE NEURONAL CALCIUM CHANNELS BY TRANSMITTERS [J].
ANWYL, R .
BRAIN RESEARCH REVIEWS, 1991, 16 (03) :265-281
[3]   NEUROTRANSMITTER INHIBITION OF NEURONAL CALCIUM CURRENTS BY CHANGES IN CHANNEL VOLTAGE DEPENDENCE [J].
BEAN, BP .
NATURE, 1989, 340 (6229) :153-156
[4]   PERTUSSIS TOXIN AND VOLTAGE DEPENDENCE DISTINGUISH MULTIPLE PATHWAYS MODULATING CALCIUM CHANNELS OF RAT SYMPATHETIC NEURONS [J].
BEECH, DJ ;
BERNHEIM, L ;
HILLE, B .
NEURON, 1992, 8 (01) :97-106
[5]   INTRACELLULAR CA2+ BUFFERS DISRUPT MUSCARINIC SUPPRESSION OF CA2+ CURRENT AND M-CURRENT IN RAT SYMPATHETIC NEURONS [J].
BEECH, DJ ;
BERNHEIM, L ;
MATHIE, A ;
HILLE, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (02) :652-656
[6]   A DIFFUSIBLE 2ND MESSENGER MEDIATES ONE OF THE PATHWAYS COUPLING RECEPTORS TO CALCIUM CHANNELS IN RAT SYMPATHETIC NEURONS [J].
BERNHEIM, L ;
BEECH, DJ ;
HILLE, B .
NEURON, 1991, 6 (06) :859-867
[7]   CHARACTERIZATION OF MUSCARINIC RECEPTOR SUBTYPES INHIBITING CA2+ CURRENT AND M-CURRENT IN RAT SYMPATHETIC NEURONS [J].
BERNHEIM, L ;
MATHIE, A ;
HILLE, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (20) :9544-9548
[8]   INHIBITION OF CA-2+ AND K+ CHANNELS IN SYMPATHETIC NEURONS BY NEUROPEPTIDES AND OTHER GANGLIONIC TRANSMITTERS [J].
BLEY, KR ;
TSIEN, RW .
NEURON, 1990, 4 (03) :379-391
[9]  
BOLAND LM, 1993, J NEUROSCI, V13, P516
[10]   PROTEIN KINASE-C IS NOT NECESSARY FOR PEPTIDE-INDUCED SUPPRESSION OF M-CURRENT OR FOR DESENSITIZATION OF THE PEPTIDE RECEPTORS [J].
BOSMA, MM ;
HILLE, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (08) :2943-2947
1234