MULTIPLE G-PROTEIN-COUPLED PATHWAYS INHIBIT N-TYPE CA CHANNELS OF NEURONS

被引：27
作者：
HILLE, B
BEECH, DJ
BERNHEIM, L
MATHIE, A
SHAPIRO, MS
WOLLMUTH, LP
机构：
[1] UNIV LEEDS,DEPT PHARMACOL,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND
[2] UNIV GENEVA,CTR MED,ECOLE MED,DEPT PHYSIOL,CH-1211 GENEVA 4,SWITZERLAND
[3] ROYAL FREE HOSP,SCH MED,DEPT PHARMACOL,LONDON NW3 2PF,ENGLAND
[4] MAX PLANCK INST MED RES,ZELLPHYSIOL ABT,D-69028 HEIDELBERG,GERMANY
来源：
LIFE SCIENCES | 1995年 / 56卷 / 11-12期
关键词：
SYMPATHETIC GANGLION; PERTUSSIS TOXIN; PIRENZEPINE; HIMBACINE; MUSCARINIC RECEPTOR;
D O I：
10.1016/0024-3205(95)00038-8
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Muscarinic receptors depress Ca2+ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists.
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页码：989 / 992
页数：4
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