Objective: To determine the effectiveness of home modification on quality of life on spinal cord injury in wheel chair user spinal cord injuries Methodology: This community based randomized control trial was carried out in district Kohat and Hangu, from January to December 2012. A total of 40 wheel chair users paraplegic patients were randomly assigned into experimental and control groups. The baseline LiSAT score was calculated. The home modification program was implemented for patients in the experiments group, including wheel chair accessible doors, ramps, rails, tub seats in bathrooms, and non-slip surfaces. LiSAT questionnaire was filled through face to face interviews before the implementation of home modifications and after two months. Results: The quality of life was significantly enhanced in the experimental group after home modification with mean LiSAT score 33.32 (p=0.001), as compared to the control group, with LiSAT score 22.85 (p=0.154), in wheel chair user paraplegic population. Conclusion: The home modification is effective in the enhancement of quality of life in wheel chair user paraplegic population.