IMPACT OF MALARIA ON GENETIC-POLYMORPHISM AND GENETIC-DISEASES IN AFRICANS AND AFRICAN-AMERICANS

被引：89

作者：

MILLER, LH

机构：

[1] Laboratory of Malaria Research, Natl. Inst. Allerg. and Infect. Dis., National Institutes of Health, Bethesda

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 07期

关键词：

D O I：

10.1073/pnas.91.7.2415

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The high mortality from malaria in sub-Sahara Africa selected multiple genes that give the population a selective advantage. Identification of the genetic basis for resistance may suggest unusual approaches to development of malarial vaccines and antimalarial drugs. Some of these genes may be deleterious, although of selective advantage within the African setting, and need to be identified for counseling for disease prevention.

引用

页码：2415 / 2419

页数：5

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