CHARACTERIZATION OF A HELA CDNA CLONE ENCODING THE HUMAN SII PROTEIN, AN ELONGATION-FACTOR FOR RNA POLYMERASE-II

被引：29

作者：

CHEN, HC ^{[1
]}

ENGLAND, L ^{[1
]}

KANE, CM ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,DIV BIOCHEM & MOLEC BIOL,401 BARKER HALL,BERKELEY,CA 94720

来源：

GENE | 1992年 / 116卷 / 02期

关键词：

TRANSCRIPTION; ANTITERMINATION; GENE REGULATION; GENETIC CONSERVATION;

D O I：

10.1016/0378-1119(92)90522-Q

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We present the cloning and sequence characterization of a HeLa cDNA encoding the SII transcription elongation factor. This cDNA clone is distinct from those previously isolated from a human kidney cDNA library [Yoo et al., Nucleic Acids Res. 19 (1991) 1073-1079]. Southern analysis suggests that more than one gene may exist for SII in the human genome. A comparison of deduced amino acid sequences for SII-related proteins from a variety of eukaryotes demonstrates very high similarity, especially within the C-terminal domain.

引用

页码：253 / 258

页数：6

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