INHIBITION OF DIHYDROFOLATE-REDUCTASE BY FOLATE ANALOGS - STRUCTURAL REQUIREMENTS FOR SLOW-BINDING AND TIGHT-BINDING INHIBITION

被引：55
|
作者：
WILLIAMS, JW
DUGGLEBY, RG
CUTLER, R
MORRISON, JF
机构：
来源：
BIOCHEMICAL PHARMACOLOGY | 1980年 / 29卷 / 04期
关键词：
D O I：
10.1016/0006-2952(80)90381-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：589 / 595
页数：7
相关论文
共 50 条
  • [41] TIGHT-BINDING INHIBITORS .9. KINETIC-PARAMETERS OF DIHYDROFOLATE-REDUCTASE INHIBITED BY METHOTREXATE, AN EXAMPLE OF EQUILIBRIUM STUDY
    CHA, S
    KIM, SYR
    KORNSTEIN, SG
    KANTOFF, PW
    KIM, KH
    NAGUIB, FNM
    BIOCHEMICAL PHARMACOLOGY, 1981, 30 (12) : 1507 - 1515
  • [42] METHOTREXATE - A TIGHT-BINDING BUT CLASSICAL COMPETITIVE INHIBITOR OF DIHYDROFOLATE-REDUCTASE FROM A METHOTREXATE RESISTANT STRAIN OF LACTOBACILLUS-CASEI
    WALTHAM, MC
    HOLLAND, JW
    ROBINSON, SC
    NIXON, PF
    WINZOR, DJ
    AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 1987, 17 (01): : 166 - 166
  • [43] NMR-STUDIES OF BINDING OF SUBSTRATE ANALOGS TO L CASEI DIHYDROFOLATE-REDUCTASE
    BURGEN, ASV
    DANN, J
    FEENEY, J
    ROBERTS, GCK
    YUFEROV, V
    BRITISH JOURNAL OF PHARMACOLOGY, 1974, 51 (01) : P126 - P127
  • [44] THREONINE SYNTHASE OF ESCHERICHIA-COLI - INHIBITION BY CLASSICAL AND SLOW-BINDING ANALOGS OF HOMOSERINE PHOSPHATE
    FARRINGTON, GK
    KUMAR, A
    SHAMES, SL
    EWASKIEWICZ, JI
    ASH, DE
    WEDLER, FC
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1993, 307 (01) : 165 - 174
  • [45] Inhibitors of prostaglandin synthase: Structural requirements for tight binding inhibition.
    Styer, A
    Clark, CA
    Kaub, CJ
    Loll, PJ
    Selinsky, BS
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U333 - U333
  • [46] SLOW-BINDING INHIBITION OF CARBOXYLESTERASE AND OTHER SERINE HYDROLASES BY CHLORODIFLUOROACETALDEHYDE
    YIN, HQ
    JONES, JP
    ANDERS, MW
    CHEMICAL RESEARCH IN TOXICOLOGY, 1993, 6 (05) : 630 - 634
  • [47] Insights into the slow-onset tight-binding inhibition of Escherichia coli dihydrofolate reductase: detailed mechanistic characterization of pyrrolo [3,2-f] quinazoline-1,3-diamine and its derivatives as novel tight-binding inhibitors
    Srinivasan, Bharath
    Skolnick, Jeffrey
    FEBS JOURNAL, 2015, 282 (10) : 1922 - 1938
  • [48] SIGNIFICANCE OF SLOW-BINDING ENZYME-INHIBITION AND ITS RELATIONSHIP TO REACTION-INTERMEDIATE ANALOGS
    SCHLOSS, JV
    ACCOUNTS OF CHEMICAL RESEARCH, 1988, 21 (09) : 348 - 353
  • [49] Translating slow-binding inhibition kinetics into cellular and in vivo effects
    Walkup, Grant K.
    You, Zhiping
    Ross, Philip L.
    Allen, Eleanor K. H.
    Daryaee, Fereidoon
    Hale, Michael R.
    O'Donnell, John
    Ehmann, David E.
    Schuck, Virna J. A.
    Buurman, Ed T.
    Choy, Allison L.
    Hajec, Laurel
    Murphy-Benenato, Kerry
    Marone, Valerie
    Patey, Sara A.
    Grosser, Lena A.
    Johnstone, Michele
    Walker, Stephen G.
    Tonge, Peter J.
    Fisher, Stewart L.
    NATURE CHEMICAL BIOLOGY, 2015, 11 (06) : 416 - +
  • [50] Translating slow-binding inhibition kinetics into cellular and in vivo effects
    Grant K Walkup
    Zhiping You
    Philip L Ross
    Eleanor K H Allen
    Fereidoon Daryaee
    Michael R Hale
    John O'Donnell
    David E Ehmann
    Virna J A Schuck
    Ed T Buurman
    Allison L Choy
    Laurel Hajec
    Kerry Murphy-Benenato
    Valerie Marone
    Sara A Patey
    Lena A Grosser
    Michele Johnstone
    Stephen G Walker
    Peter J Tonge
    Stewart L Fisher
    Nature Chemical Biology, 2015, 11 : 416 - 423
12345