Shared links between type 2 diabetes mellitus and Alzheimer's disease: A review

被引：103
作者：
Mittal, Khyati [1 ]
Katare, Deepshikha Pande [1 ]
机构：
[1] Amity Univ, Prote & Translat Res Lab, Ctr Med Biotechnol, Amity Inst Biotechnol, Noida, Uttar Pradesh, India
来源：
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS | 2016年 / 10卷 / 02期
关键词：
Alzheimer's disease; Type; 3; diabetes; Type 2 diabetes mellitus; Shared links;
D O I：
10.1016/j.dsx.2016.01.021
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Epidemiological studies have proved that, there are pathophysiological connections between Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD). Diabetic patients have higher incidences of cognitive impairment and hence they are more at the risk of developing AD. Some of the recent evidences have majorly stated the effects of insulin resistance in the disturbance of various biological processes and signaling pathways. Both hyperglycemia and hypoglycemic conditions contributes in dysfunctioning of cognitive abilities and functions. The present review summarizes the evidences which establish the possible links between the two pathologies on the account of molecular, biochemical and at histopathological level. The information regarding their interactions was collected from different databases and journals. The gathered information will clearly establish the link among the two pathologies and will be helpful in future for the development of drugs for Type 3 Diabetes. (C) 2016 Diabetes India. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：S144 / S149
页数：6
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