BCL-2 IS AN INNER MITOCHONDRIAL-MEMBRANE PROTEIN THAT BLOCKS PROGRAMMED CELL-DEATH

被引：3653
作者：
HOCKENBERY, D
NUNEZ, G
MILLIMAN, C
SCHREIBER, RD
KORSMEYER, SJ
机构：
[1] WASHINGTON UNIV,SCH MED,HOWARD HUGHES MED INST,DEPT MOLEC MICROBIOL,ST LOUIS,MO 63110
[2] WASHINGTON UNIV,SCH MED,HOWARD HUGHES MED INST,DEPT PATHOL,ST LOUIS,MO 63110
来源：
NATURE | 1990年 / 348卷 / 6299期
关键词：
D O I：
10.1038/348334a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
THE t(14; 18) chromosomal translocation of human follicular B-cell lymphoma juxtaposes the bcl-2 gene with the immunoglobulin heavy chain locus1-3. The bcl-2 immunoglobulin fusion gene is markedly deregulated resulting in inappropriately elevated levels of bcl-2 RNA and protein4-7. Transgenic mice bearing a bcl-2 immunoglobulin minigene demonstrate a polyclonal expansion of resting yet responsive IgM-IgD B cells which display prolonged cell survival but no increase in cell cycling8,9. Moreover, deregulated bcl-2 extends the survival of certain haematopoietic cell lines following growth-factor deprivation10,11. By using immunolocalization studies we now demonstrate that Bcl-2 is an integral inner mitochondrial membrane protein of relative molecular mass 25,000 (25k). Overexpression of Bcl-2 blocks the apoptotic death of a pro-B-lymphocyte cell line. Thus, Bcl-2 is unique among proto-oncogenes, being localized to mitochondria and interfering with programmed cell death independent of promoting cell division. © 1990 Nature Publishing Group.
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页码：334 / 336
页数：3
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