REGULATION OF HEME-REGULATED EIF-2-ALPHA KINASE AND ITS EXPRESSION IN ERYTHROID-CELLS

被引：20
作者：
CHEN, JJ [1 ]
CROSBY, JS [1 ]
LONDON, IM [1 ]
机构：
[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02139
来源：
BIOCHIMIE | 1994年 / 76卷 / 08期
关键词：
TRANSLATION; PROTEIN KINASE; HEME; ERYTHROID; INITIATION;
D O I：
10.1016/0300-9084(94)90080-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this article we focus first on the molecular mechanisms controlling the activity of the heme-regulated translational inhibitor, HRI, in erythroid cells. Then we discuss the tissue-specific expression of HRI. The experimental evidence obtained to date indicates that the major physiological role of HRI is in adjusting the synthesis of globin to the availability of heme.
引用
收藏
页码：761 / 769
页数：9
相关论文
共 73 条
[1]  
ANDREWS NC, 1993, NATURE, V326, P722
[2]  
BAEK KJ, 1993, J BIOL CHEM, V268, P21120
[3]  
BECK WS, 1991, HEMATOLOGY
[4]   REGULATION OF EUKARYOTIC TRANSLATION INITIATION-FACTOR EXPRESSION DURING T-CELL ACTIVATION [J].
BOAL, TR ;
CHIORINI, JA ;
COHEN, RB ;
MIYAMOTO, S ;
FREDERICKSON, RM ;
SONENBERG, N ;
SAFER, B .
BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1176 (03) :257-264
[5]   REDUCED FORMATION OF INITIATION-COMPLEXES BETWEEN MET-TRANSFER-RNA-F AND 40-S RIBOSOMAL-SUBUNITS IN RABBIT RETICULOCYTE LYSATES INCUBATED AT ELEVATED-TEMPERATURES - ACTIVITY OF MET-TRANSFER-RNA-F BINDING FACTOR [J].
BONANOUTZEDAKI, SA ;
SMITH, KE ;
SHEERAN, BA ;
ARNSTEIN, HRV .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1978, 84 (02) :601-610
[6]  
CHEFALO PJ, IN PRESS J BIOL CHEM
[7]   AMINO-ACID MICROSEQUENCING OF INTERNAL TRYPTIC PEPTIDES OF HEME-REGULATED EUKARYOTIC INITIATION-FACTOR 2-ALPHA SUBUNIT KINASE - HOMOLOGY TO PROTEIN-KINASES [J].
CHEN, JJ ;
PAL, JK ;
PETRYSHYN, R ;
KUO, I ;
YANG, JM ;
THROOP, MS ;
GEHRKE, L ;
LONDON, IM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (02) :315-319
[8]  
CHEN JJ, 1989, J BIOL CHEM, V264, P9559
[9]   CLONING OF THE CDNA OF THE HEME-REGULATED EUKARYOTIC INITIATION FACTOR-2-ALPHA (EIF-2-ALPHA) KINASE OF RABBIT RETICULOCYTES - HOMOLOGY TO YEAST GCN2 PROTEIN-KINASE AND HUMAN DOUBLE-STRANDED-RNA-DEPENDENT EIF-2-ALPHA KINASE [J].
CHEN, JJ ;
THROOP, MS ;
GEHRKE, L ;
KUO, I ;
PAL, JK ;
BRODSKY, M ;
LONDON, IM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (17) :7729-7733
[10]  
CHEN JJ, 1993, TRANSLATIONAL REGULA, V2, P349
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