DETECTION OF CHOLINE-ACETYLTRANSFERASE ACTIVITY IN LYMPHOCYTES

被引：67

作者：

RINNER, I

SCHAUENSTEIN, K

机构：

[1] Institute of General and Experimental Pathology, University of Graz, Graz

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 1993年 / 35卷 / 02期

关键词：

IMMUNE-NEUROENDOCRINE INTEGRATION; MUSCARINIC RECEPTORS; NICOTINIC RECEPTORS; ACETYLCHOLINE-ESTERASE; CHOLINERGIC RECEPTORS;

D O I：

10.1002/jnr.490350209

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The cholinergic system takes part in the immune-neuroendocrine integration. Lymphocytes have been found to express muscarinic and nicotinic cholinergic receptors, as well as acetylcholine-esterase on their surface, and cholinergic agents modulate immune functions in vitro and in vivo. In the present study we provide evidence that purified organ resident and circulating lymphocytes, as well as various lymphoid cell lines derived from different species, exhibit choline-acetyltransferase activity and, therefore, have the potential to produce the neurotransmitter acetylcholine.

引用

页码：188 / 191

页数：4

共 22 条

[1] CHOLINE-ACETYLTRANSFERASE IN HUMAN CEREBROSPINAL-FLUID - NON-ENZYMATICALLY AND ENZYMATICALLY CATALYZED ACETYLCHOLINE SYNTHESIS [J].