TARGET-CELLS FOR 1,25-DIHYDROXYVITAMIN-D3 IN INTESTINAL-TRACT, STOMACH, KIDNEY, SKIN, PITUITARY, AND PARATHYROID

被引：614

作者：

STUMPF, WE

SAR, M

REID, FA

TANAKA, Y

DELUCA, HF

机构：

[1] UNIV N CAROLINA,DEPT PHARMACOL,CHAPEL HILL,NC 27514

[2] UNIV WISCONSIN,DEPT BIOCHEM,MADISON,WI 53706

来源：

SCIENCE | 1979年 / 206卷 / 4423期

关键词：

D O I：

10.1126/science.505004

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

After mature rats that had been fed on a vitamin D3-deficient diet were injected with tritium-labeled 1,25-dihydroxyvitamin D3, radioactivity became concentrated in nuclei of luminal and cryptal epithelium of the duodenum, jejunum, ileum, colon; in nuclei of the epithelium of kidney distal tubules including the macula densa, and in podocytes of glomeruli; in nuclei of the epidermis including outer hair-shafts and sebaceous glands; and in nuclei of certain cells of the stomach, anterior and posterior pituitary, and parathyroid. These results reveal cell types that contain receptors for 1,25-dihydroxyvitamin D3 or metabolites of this compound both in known or hypothesized target tissues and in tissues that were previously unknown to participate in vitamin D3 metabolism. Copyright © 1979 AAAS.

引用

页码：1188 / 1190

页数：3

共 23 条

[1]

[Anonymous], 1976, RECEPTORS MECH ACTIO

[2]

Cooper C W, 1978, Recent Prog Horm Res, V34, P259

[3] METABOLISM AND MECHANISM OF ACTION OF VITAMIN-D1 [J].