ASSISTING SPONTANEITY - THE ROLE OF HSP90 AND SMALL HSPS AS MOLECULAR CHAPERONES

被引：340
作者：
JAKOB, U
BUCHNER, J
机构：
[1] U. Jakob and J. Buchner are, the Institut für Biophysik und Physikalische Biochemie, Universität Regensburg
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 05期
关键词：
D O I：
10.1016/0968-0004(94)90023-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hsp90 and small Hsps are two abundant types of eukaryotic stress protein whose function has remained largely enigmatic. In the cell, Hsp90 exists in a complex (with other Hsps and prolyl isomerases) possibly implicated in interactions with non-native proteins. Recent biochemical analysis of both Hsp90 and small Hsps has revealed that they may act as ATP-independent molecular chaperones involved in protein folding and unfolding events.
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页码：205 / 211
页数：7
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