TIAZOFURIN-INDUCED CHANGES IN INOSITOL LIPID CYCLE IN NUCLEI OF FRIEND-ERYTHROLEUKEMIA CELLS

被引：27
|
作者：
BILLI, AM
COCCO, L
MARTELLI, AM
GILMOUR, RS
WEBER, G
机构：
[1] IST ANAT UMANA NORMALE, V IRNERIO 48, I-40126 BOLOGNA, ITALY
[2] DIPARTIMENTO MORFOL UMANA, I-34138 TRIESTE, ITALY
[3] AFRC, INST ANIM PHYSIOL & GENET RES, DEPT MOLEC & CELLULAR PHYSIOL, CAMBRIDGE CB2 4AT, ENGLAND
[4] INDIANA UNIV, SCH MED, EXPTL ONCOL LAB, INDIANAPOLIS, IN 46202 USA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 195卷 / 01期
关键词：
D O I：
10.1006/bbrc.1993.2001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
When murine erythroleukemia cells are treated up to 96 hrs with the antitumor drug tiazofurin the induction of erythroid differentiation is accompanied by changes in both synthesis and breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5 bisphosphate in the nucleus. These changes, which parallel the effect of dimethylsulfoxide, a well known inducer of erythroid differentiation in vitro, are due to the inhibition of the nuclear phosphoinositidase C activity. Therefore the present data indicate the nuclear inositol lipid cycle as a target of tiazofurin in addition to its inhibition of IMP dehydrogenase (EC 1.1.1.205) activity. © 1993 Academic Press, Inc.
引用
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页码：8 / 12
页数：5
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