Determination of the stability of Kollicoat MAE 30D by means of differential scanning calorimetry

被引：0

作者：

Ruiz, Ma A. ^{[1
]}

Lopez-Viota, M. ^{[1
]}

Arias, J. L. ^{[1
]}

Gallardo, V ^{[1
]}

机构：

[1] Univ Granada, Fac Farm, Dept Farm & Tecnol Farmaceut, Campus Cartuja, E-18071 Granada, Spain

来源：

ARS PHARMACEUTICA | 2008年 / 49卷 / 01期

关键词：

Nanomaterials; Biocompatible polymers; Kollicoat; DSC; SEM;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The stability of Kollicoat MAE 30 D was studied with differential scanning calorimetric, and scanning electron microscopy. We investigated the effects of pH, temperature and shaking on physicochemical properties of the latex particles. Stability of the polymer as most strongly affected by pH; hence, we conclude that the stability of this latex reaches a maximum at acid pH values, where as stability is lost to pH 6. The particle shape and the mean diameter were determined by means of SEM microphotographs on 200 particles in a sample of dry latex. The aqueous Kollicoat MAE 30 D dispersion, at its natural pH (2.5), presented one population of particles with a mean diameter of 1.56 nm.

引用

页码：66 / 75

页数：10

共 15 条

[1]

Allen T., 1981, PARTICLE SIZE MEASUR

[2]

[Anonymous], 1993, EASTMAN FINE CHEM

[3] Comparative studies with Kollicoat MAE 30 D and Kollicoat MAE 30 DP in aqueous spray dispersions and enteric coatings on highly swellable caffeine cores [J].

Dangel, C ;

Schepky, G ;

Reich, HB ;

Kolter, K .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2000, 26 (04) :415-421

[4] Thermal analysis of some environmentally degradable polymers [J].

Day, M ;

Cooney, JD ;

Shaw, K ;

Watts, J .

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 1998, 52 (02) :261-274

[5] Synthesis and characterization of new aryl-oxycarbonyl methyl methacrylate monomers and their polymers [J].

Erol, I ;

Soykan, C .

REACTIVE & FUNCTIONAL POLYMERS, 2003, 56 (03) :147-157

[6] The use of differential scanning calorimetry to identify coals susceptible to spontaneous combustion [J].

Garcia, P ;

Hall, PJ ;

Mondragon, F .

THERMOCHIMICA ACTA, 1999, 336 (1-2) :41-46

[7]

GURNY R, 1981, PHARM ACTA HELV, V56, P130

[8]

Gurny R., 1985, FORMES PHARM NOUVELL, P657

[9]

Kollicoat MAE, FILE

[10]

Lehmann K. O. R, 1989, PHARM DOSAGE FORMS, P153

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