EFFERVESCENT RANITIDINE FOR THE TREATMENT OF DUODENAL-ULCER DISEASE - RESULTS OF A MULTICENTER TRIAL

被引：0

作者：

SCHMITZ, D ^{[1
]}

HENDRIX, R ^{[1
]}

BEKER, H ^{[1
]}

GERAEDTS, EAM ^{[1
]}

MILLS, JG ^{[1
]}

WOOD, JR ^{[1
]}

机构：

[1] GLAXO GRP RES LTD,DIV GASTROENTEROL,GREENFORD RD,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 1992年 / 4卷 / 07期

关键词：

RANITIDINE; EFFERVESCENT TABLET; DUODENAL ULCER;

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objective: Comparison of the efficacy and safety of ranitidine 150 mg twice daily, given as standard or effervescent tablets, in the treatment of duodenal ulcers. Design: An international multicentre double-blind, parallel group study. Setting: Hospital outpatient department. Patients: Four hundred and twenty-seven patients, aged 18 years and over, with an endoscopically proven duodenal ulcer measuring at least 5 mm in diameter, were recruited to the study- Follow-up endoscopy results were available for 405 patients. Interventions: Patients were allocated to treatment with ranitidine 150 mg twice daily given either as effervescent or standard tablets. Treatment continued for 4 weeks. Main outcome measures: The primary outcome measure was ulcer healing after 4 weeks. In addition, the effects of treatment on ulcer-related symptoms were examined. Results: After 4 weeks ulcers were healed in 87 and 88% of patients receiving the effervescent and standard tablet formulations, respectively. The median time to pain relief was 4 days in both treatment groups. Ranitidine effervescent tablets were well tolerated and compliance was good. Conclusions: Ranitidine effervescent tablets offer a safe, palatable and efficacious alternative to the solid dosage form.

引用

页码：569 / 572

页数：4