RIBOSOMAL MOVEMENT IMPEDED AT A PSEUDOKNOT REQUIRED FOR FRAMESHIFTING

被引：160

作者：

TU, CL ^{[1
]}

TZENG, TH ^{[1
]}

BRUENN, JA ^{[1
]}

机构：

[1] SUNY BUFFALO, DEPT BIOL SCI, BUFFALO, NY 14260 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 18期

关键词：

DOUBLE-STRANDED RNA VIRUS; SACCHAROMYCES-CEREVISIAE VIRUS; TRANSLATION; YEAST;

D O I：

10.1073/pnas.89.18.8636

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Translational frameshifting sometimes occurs when ribosomes encounter a "shift" site preceding a region of unusual secondary structure, which in at least three cases is known to be a pseudoknot. We provide evidence that ribosomes have a decreased rate of movement through a pseudoknot required for frameshifting. These paused ribosomes are directly situated over the shift sequence. Ribosomal pausing appears to be necessary but not sufficient for frameshifting.

引用

页码：8636 / 8640

页数：5

共 25 条

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