STABILIZATION OF A NEW ANTIULCER DRUG (LANSOPRAZOLE) IN THE SOLID DOSAGE FORMS

被引：32
|
作者：
TABATA, T
MAKINO, T
KASHIHARA, T
HIRAI, S
KITAMORI, N
TOGUCHI, H
机构：
[1] Pharmaceutics Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd., Osaka, 532, 17-85
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1992年 / 18卷 / 13期
关键词：
LANSOPRAZOLE; ENTERIC GRANULES; MAGNESIUM CARBONATE; MECHANISM OF STABILIZATION; STABILIZER;
D O I：
10.3109/03639049209040850
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In the previous study, we clarified that enteric granules were appropriate dosage forms of lansoprazole, The establishment of these formulations, however, was difficult because some of the excipients needed for these formulations are incompatible with the drug. We examined the effects of adding magnesium carbonate as an alkaline stabilizer and could get stable enteric granules. We also discuss the mechanism of stabilization.
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页码：1437 / 1447
页数：11
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