ENANTIOSELECTIVE BORANE REDUCTION OF KETONES CATALYZED BY A CHIRAL OXAZAPHOSPHOLIDINE BORANE COMPLEX

被引：45

作者：

BRUNEL, JM ^{[1
]}

PARDIGON, O ^{[1
]}

FAURE, B ^{[1
]}

BUONO, G ^{[1
]}

机构：

[1] UNIV AIX MARSEILLE 3,FAC SCI & TECH ST JEROME,F-13397 MARSEILLE 13,FRANCE

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 03期

关键词：

D O I：

10.1039/c39920000287

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The chiral oxazaphospholidine-borane complex 2 was used as catalyst (2 mol %) in asymmetric reduction of ketones by borane with an enantioselectivity ranging from 33 to 92% at 110-degrees-C and 100% conversion; under stoichiometric conditions the reduction proceeded with 99% enantiomeric excess.

引用

页码：287 / 288

页数：2