REVERSIBLE INHIBITION OF RENAL MICROSOME CALCIUM-PUMP BY FUROSEMIDE

被引：12
|
作者：
MOORE, L
LANDON, EJ
机构：
[1] UNIFORMED SERV UNIV, DEPT PHARMACOL, BETHESDA, MD 20014 USA
[2] VANDERBILT UNIV, DEPT PHARMACOL, NASHVILLE, TN 37232 USA
来源：
LIFE SCIENCES | 1979年 / 25卷 / 12期
关键词：
D O I：
10.1016/0024-3205(79)90588-5
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Rat renal microsomes have an energy-dependent Ca pump activity. Diuretic compounds (3) inhibit this Ca pump in vitro. Characterization of furosemide inhibition shows that this agent is a reversible, non-competitive inhibitor of the renal microsome Ca pump. Furosemide, under similar conditions does not inhibit Na/K-ATPase activity in the renal microsome fraction. Furosemide may be useful to define function of the microsomal Ca pump in non-muscle cells.
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页码：1029 / 1034
页数：6
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