MINERALOCORTICOID REPLACEMENT IN ADDISONS-DISEASE

被引：26
作者：
THOMPSON, DG [1 ]
MASON, AS [1 ]
GOODWIN, FJ [1 ]
机构：
[1] LONDON HOSP, DEPT METAB & ENDOCRINOL, LONDON E1 1BB, ENGLAND
来源：
CLINICAL ENDOCRINOLOGY | 1979年 / 10卷 / 05期
关键词：
D O I：
10.1111/j.1365-2265.1979.tb02107.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Eight patients with treated Addison's disease were studied whilst receiving different doses of fludrocortisone together with a constant intake of glucocorticoid. Plasma renin activity (PRA), blood pressure, pulse rate and plasma potassium and urea concentrations were measured after 2‐week periods on each dose. In two patients, PRA measurements indicated that mineralocorticoid replacement therapy had been inadequate. In four others, PRA remained normal throughout the study, even after fludrocortisone had been discontinued, suggesting that the drug was unnecessary for the maintenance of normal sodium balance in these patients. Asymptomatic fludrocortisone overdosage was indicated by a low plasma potassium concentration, but not by PRA measurements which failed in this study to distinguish between adequate and excessive mineralocorticoid replacement. Copyright © 1979, Wiley Blackwell. All rights reserved
引用
收藏
页码：499 / 506
页数：8
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