STRAND SYMMETRY OF MUTATION-RATES IN THE BETA-GLOBIN REGION

被引：23
作者：
BULMER, M [1 ]
机构：
[1] DEPT STAT,OXFORD OX1 3TG,ENGLAND
来源：
JOURNAL OF MOLECULAR EVOLUTION | 1991年 / 33卷 / 04期
关键词：
STRAND SYMMETRY; BETA-GLOBIN; MUTATION RATES; TRANSITION TRANSVERSION BIAS; PURINE PYRIMIDINE RATIO;
D O I：
10.1007/BF02102861
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
It has been suggested that there may be inequalities in the types of substitution on the two DNA strands (in particular, in the frequencies of transversions from R to Y and from Y to R) due to a higher error rate on the lagging than the leading strand during replication. Reexamination of 11 kb of the beta-globin region sequenced in six primates fails to confirm this suggestion. Examination of the 73-kb beta-globin region sequenced in humans shows that the frequency of pyrimidines in different parts of this region is more variable than expected in a random sequence, but the pattern is more consistent with nonrandomness generated by DNA turnover mechanisms than with strand asymmetry due to a higher error rate on the lagging strand.
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页码：305 / 310
页数：6
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