A STUDY OF THE POLYMORPHISM RS9939609 OF THE FTO GENE AND RS738409 OF THE PNPLA3 GENE AS RISK FACTORS FOR THE DEVELOPMENT OF NAFLD IN THE YAKUT POPULATION OF TYPE 2 DIABETES MELLITUS

In order to study the frequency distribution of the polymorphism alleles rs9939609 of the FTO gene and polymorphism rs738409 of the PNPLA3 gene among the Yakuts, 132 DNA samples of patients with type 2 diabetes and 70 DNA samples of healthy volunteers were tested. The study of the frequency distribution of the polymorphism alleles rs9939609 of the FTO gene and polymorphism rs738409 of the PNPLA3 gene in both groups showed no significant differences. Analysis of the frequency distribution of alleles and genotypes of the polymorphic variant of the FTO gene (rs9939609) in the group of patients with type 2 diabetes and healthy revealed a predominance of the T allele and a homozygous genotype of TT, except for a group of practically healthy men, which despite the prevalence of the T allele was characterized by the highest level of the heterozygous genotype AT. When analyzing the frequency distribution of the alleles and genotypes of the polymorphic version of the PNPLA3 gene (rs738409), the allele G and the homozygous genotype GG prevailed in both groups. In the men and both groups studied, the G allele significantly prevailed over the C allele (p<0.05).