IDIOSPERMULINE, A TRIMERIC PYRROLIDINOINDOLINE ALKALOID FROM THE SEED OF IDIOSPERMUM AUSTRALIENSE

被引：40

作者：

DUKE, RK ^{[1
]}

ALLAN, RD ^{[1
]}

JOHNSTON, GAR ^{[1
]}

MEWETT, KN ^{[1
]}

MITROVIC, AD ^{[1
]}

DUKE, CC ^{[1
]}

HAMBLEY, TW ^{[1
]}

机构：

[1] UNIV SYDNEY,SCH CHEM,DEPT PHARM,SYDNEY,NSW 2006,AUSTRALIA

来源：

JOURNAL OF NATURAL PRODUCTS-LLOYDIA | 1995年 / 58卷 / 08期

关键词：

D O I：

10.1021/np50122a007

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Purificarion of a methanol extract from the seed of Idiospermum australiense, guided by bioactivity on a rat brain cortical wedge preparation has afforded two known dimeric alkaloids, the piperidinoindoline, (+)-calycanthine [1] and the pyrrolidinoindoline, (-)-chimonanthine [2] along with a new trimeric pyrrolidinoindoline alkaloid, (-)-idiospermuline [3]. The structure of idiospermuline [3] was determined by spectroscopic methods and the absolute configuration by an X-ray crystallographic study of idiospermuline trimethiodide [4].

引用

页码：1200 / 1208

页数：9

共 24 条

[1] HODGKINSINE, ALKALOID OF HODGKINSONIA FRUTESCENS F MUELL [J].

ANET, EF ;

HUGHES, GK ;

RITCHIE, E .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1961, 14 (01) :173-&

[2]

Blake ST, 1972, CONTRIB QUEENSL HERB, V12, P1

[3]

Creagh D. C. M. W. J., 1992, INT TABLES CRYSTALLO, P219

[4]

Cromer D.T, 1974, INT TABLES XRAY CRYS, VIV

[5]

DIELS L, 1912, BOT JB, V48, P107

[6] RESOLUTION, ABSOLUTE STEREOCHEMISTRY, AND PHARMACOLOGY OF THE S-(+)-ISOMERS AND R-(-)-ISOMERS OF THE APPARENT PARTIAL AMPA RECEPTOR AGONIST (R,S)-2-AMINO-3-(3-HYDROXY-5-PHENYLISOXAZOL-4-YL)PROPIONIC ACID [(R,S)-APPA] [J].

EBERT, B ;

LENZ, S ;

BREHM, L ;

BREGNEDAL, P ;

HANSEN, JJ ;

FREDERIKSEN, K ;

BOGESO, KP ;

KROGSGAARDLARSEN, P .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (07) :878-884

[7]

EVANS RH, 1989, NMDA RECEPTOR, P69

[8]

EVERIST SL, 1981, POISONOUS PLANTS AUS, P371

[9] ABSOLUTE MOLECULAR-STRUCTURE OF HODGKINSINE [J].

FRIDRICHSONS, J ;

MACKAY, MF ;

MATHIESON, AM .

TETRAHEDRON, 1974, 30 (01) :85-92

[10] NOVEL CA2+-ATPASE INHIBITORS FROM THE DRIED ROOT TUBERS OF POLYGONUM-MULTIFLORUM [J].

GRECH, JN ;

LI, Q ;

ROUFOGALIS, BD ;

DUKE, CC .

JOURNAL OF NATURAL PRODUCTS, 1994, 57 (12) :1682-1687

← 1 2 3 →