THE INFLUENCE OF ANESTHETIC DRUGS ON THE LOWER ESOPHAGEAL SPHINCTER IN PROPOFOL/NITROUS OXIDE ANESTHETIZED DOGS - PRESSURE PROFILOMETRY IN AN ANIMAL-MODEL

被引：0

作者：

VANDERHOEVEN, CWP ^{[1
]}

ATTIA, A ^{[1
]}

DEEN, L ^{[1
]}

KLOPPER, PJ ^{[1
]}

机构：

[1] ACAD MED CTR,DEPT ANAESTHESIOL,1105 AZ AMSTERDAM,NETHERLANDS

来源：

ACTA ANAESTHESIOLOGICA SCANDINAVICA | 1995年 / 39卷 / 06期

关键词：

ANESTHESIA; ANIMAL MODEL; CISAPRIDE; LOWER ESOPHAGEAL SPHINCTER; PANCURONIUM; PROPOFOL; SUXAMETHONIUM; 3-DIMENSIONAL PRESSURE PROFILOMETRY; VECURONIUM;

D O I：

暂无

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The lower oesophageal sphincter (LES) is the main barrier against gastro-oesophageal reflux. Various anaethetic drugs have been reported to affect the LES pressure. In this study, the effects of cisapride, atropine, suxamethonium um, vecuronium and pancuronium on the LES pressure of six mongrel dogs anaesthetized with propofol and nitrous oxide were investigated. By means of eight-channel pressure profilometry the LES pressure was measured. in consecutive sessions before and after administration of each drug. Compared to basal values, atropine suxamethonium significantly decreased LES pressure, pressure vector volume and sphincter length. Ci significantly increased all sphincter parameters, vecuronium significantly increased LES pressure and pressure vector volume while pancuronium had no significant effects. A significant decrease of the LES pressure pressure vector volume was observed when nitrous oxide was omitted from the ventilation mixture. Three-dimensional imaging showed an asymmetric shape of the LES pressure which resulted from radial differences the LES pressure. The results from this study shaw that both the anaesthetic animal model and the eight-channel pressure profilometry are useful procedures in studying the effects on sphincter function of different drugs anaesthesia.

引用

页码：822 / 826

页数：5