EXPRESSION OF PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) AND NUCLEOLAR ORGANIZER REGIONS (NORS) IN MULTIPLE-MYELOMA

被引：0

作者：

SKOPELITOU, A

TSELENIS, S

THEOCHARIS, S

AGNANTIS, N

TSENGA, A

ELEMENOGLOU, J

HADJIYANNAKIS, M

KITTAS, C

机构：

[1] UNIV ATHENS,SCH MED,DEPT PATHOL,HAEMATOPATHOL SECT,GR-11527 GOUDI,GREECE

[2] UNIV IOANNINA,SCH MED,DEPT PATHOL,GR-45110 IOANNINA,GREECE

[3] TZANEION GEN HOSP,DEPT PATHOL,PIRAEUS,GREECE

[4] UNIV ATHENS,SCH MED,DEPT PATHOL PHYSIOL,GR-11527 GOUDI,GREECE

来源：

ANTICANCER RESEARCH | 1994年 / 14卷 / 3A期

关键词：

MULTIPLE MYELOMA; PCNA; AGNORS;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have studied 72 cases of multiple myeloma (MM) bone marrow trephine biopsies using the monoclonal antibody PC-10 and the colloid silver nitrate method for identification of proliferating cell nuclear antigen (PCNA) and nucleolar organizer regions (NORs), respectively. PC-10 and AgNOR scores were statistically significantly different between low versus intermediate and low versus high grade of malignancy (P<0.001), whereas their difference was not significant between intermediate and high grade. A strong correlation was identified between these two proliferation-associated indices in each histological grade. There is evidence that the proliferative state of myelomas belonging to the intermediate grade is approximately the same as that observed in high grade (blastic) ones.

引用

页码：787 / 792

页数：6

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