THERAPY OF CHRONIC VIRAL-HEPATITIS

被引：0

作者：

GOESER, T ^{[1
]}

THEILMANN, L ^{[1
]}

机构：

[1] UNIV HEIDELBERG, MED KLIN, DEPT MED, D-69115 HEIDELBERG, GERMANY

来源：

INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS | 1994年 / 32卷 / 11期

关键词：

HBV; HCV; HDV; INTERFERON THERAPY; CHRONIC VIRAL HEPATITIS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Interferon is currently the only established therapeutical option for chronic viral hepatitis. Sustained response can be achieved in approximately 25% of patients with chronic HBV or HCV infection. Results in chronic HDV infection are disappointing. Whether combination of interferon with other lymphokines or antiviral drugs will lead to higher response rates, remains to be established. The argument that interferon will only place spontaneous seroconversion on an earlier date has not been disproved yet. Long-term follow-ups are necessary to show that therapy with interferon will improve survival and reduce the incidence of hepatocellular carcinoma in patients with chronic viral hepatitis.

引用

页码：571 / 576

页数：6

共 40 条

[1] HEPATITIS-C VIREMIA AND LIVER-DISEASE IN SYMPTOM-FREE INDIVIDUALS WITH ANTI-HCV [J].

ALBERTI, A ;

MORSICA, G ;

CHEMELLO, L ;

CAVALLETTO, D ;

NOVENTA, F ;

PONTISSO, P ;

RUOL, A .

LANCET, 1992, 340 (8821) :697-698

[2] DETECTION OF ANTIBODY TO HEPATITIS-C VIRUS IN PROSPECTIVELY FOLLOWED TRANSFUSION RECIPIENTS WITH ACUTE AND CHRONIC NON-A-HEPATITIS, NON-B-HEPATITIS [J].

ALTER, HJ ;

PURCELL, RH ;

SHIH, JW ;

MELPOLDER, JC ;

HOUGHTON, M ;

CHOO, QL ;

KUO, G .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (22) :1494-1500

[3] THE NATURAL-HISTORY OF COMMUNITY-ACQUIRED HEPATITIS-C IN THE UNITED-STATES [J].

ALTER, MJ ;

MARGOLIS, HS ;

KRAWCZYNSKI, K ;

JUDSON, FN ;

MARES, A ;

ALEXANDER, WJ ;

HU, PY ;

MILLER, JK ;

GERBER, MA ;

SAMPLINER, RE ;

MEEKS, EL ;

BEACH, MJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (27) :1899-1905

[4]

BEASLEY RP, 1981, LANCET, V2, P1129

[5] RECOMBINANT INTERFERON-ALPHA FOR CHRONIC HEPATITIS-C IN PATIENTS POSITIVE FOR ANTIBODY TO HUMAN-IMMUNODEFICIENCY-VIRUS [J].

BOYER, N ;

MARCELLIN, P ;

DEGOTT, C ;

DEGOS, F ;

SAIMOT, AG ;

ERLINGER, S ;

BENHAMOU, JP .

JOURNAL OF INFECTIOUS DISEASES, 1992, 165 (04) :723-726

[6] WHICH PATIENTS WITH CHRONIC HEPATITIS-B VIRUS-INFECTION WILL RESPOND TO ALPHA-INTERFERON THERAPY - A STATISTICAL-ANALYSIS OF PREDICTIVE FACTORS [J].

BROOK, MG ;

KARAYIANNIS, P ;

THOMAS, HC .

HEPATOLOGY, 1989, 10 (05) :761-763

[7]

CARRENO V, 1989, ABSTRACT BOOK MONTE, P17

[8] COMPARISON OF 1 OR 3 MU OF INTERFERON ALFA-2B AND PLACEBO IN PATIENTS WITH CHRONIC NON-A, NON-B HEPATITIS [J].

CAUSSE, X ;

GODINOT, H ;

CHEVALLIER, M ;

CHOSSEGROS, P ;

ZOULIM, F ;

OUZAN, D ;

HEYRAUD, JP ;

FONTANGES, T ;

ALBRECHT, J ;

MESCHIEVITZ, C ;

TREPO, C .

GASTROENTEROLOGY, 1991, 101 (02) :497-502

[9]

CHAYAMA K, 1991, HEPATOLOGY, V13, P1040

[10] TREATMENT OF CHRONIC HEPATITIS-C WITH RECOMBINANT INTERFERON-ALFA - A MULTICENTER RANDOMIZED, CONTROLLED TRIAL [J].

DAVIS, GL ;

BALART, LA ;

SCHIFF, ER ;

LINDSAY, K ;

BODENHEIMER, HC ;

PERRILLO, RP ;

CAREY, W ;

JACOBSON, IM ;

PAYNE, J ;

DIENSTAG, JL ;

VANTHIEL, DH ;

TAMBURRO, C ;

LEFKOWITCH, J ;

ALBRECHT, J ;

MESCHIEVITZ, C ;

ORTEGO, TJ ;

GIBAS, A .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (22) :1501-1506

← 1 2 3 4 →