DEHYDROEPIANDROSTERONE - THE MISSING LINK BETWEEN HYPERINSULINEMIA AND ATHEROSCLEROSIS

被引：106
作者：
NESTLER, JE
CLORE, JN
BLACKARD, WG
机构：
[1] Division of Endocrinology/Metabolism, Medical College of Virginia, Box 111, Richmond
来源：
FASEB JOURNAL | 1992年 / 6卷 / 12期
关键词：
DEHYDROEPIANDROSTERONE; INSULIN; ATHEROSCLEROSIS; AGING; OBESITY;
D O I：
10.1096/fasebj.6.12.1387859
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A well-established epidemiologic association exists between hyperinsulinemia and macrovascular disease. However, the mechanism or mechanisms by which hyperinsulinemia promotes atherogenesis is unknown. Recent evidence indicates that the adrenal steroid dehydroepiandrosterone (DHEA) exerts multiple antiatherogenic effects and also suggests that hyperinsulinemia may reduce serum DHEA and DHEA-sulfate levels by decreasing production and enhancing metabolic clearance. We advance the hypothesis that hyperinsulinemia promotes macrovascular disease in part by reducing serum DHEA and DHEA-sulfate levels and illustrate how this may be the case in two clinical conditions characterized by hyperinsulinemic insulin resistance: aging and obesity.
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页码：3073 / 3075
页数：3
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