CRYSTAL AND MOLECULAR-STRUCTURES OF PYRIDAZINONE CARDIOVASCULAR AGENTS

The crystal and molecular structures of 11 6-substituted pyridazinone derivatives: 6-phenyl-3(2H)-pyridazinone-acetic acid (1/1) (1), 6-(4-aminophenyl)-3(2H)-pyridazinone (2), 6-(4-aminophenyl)-5-methyl-3(2H)-pyridazinone (3), 6-(4-acetamido-phenyl)-3(2H)-pyridazinone (4), 6-(4-acetamido-2-methoxyphenyl)-3(2H)-pyridazinone (5), 6-(2-aminophenyl)-3(2H)-pyridazinone (6), 6-phenyl-3(2H)-pyrazinone (7), 6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone (8), (R)-(-)-6-[4-(3-bromopropionamido)phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone (9). (R)-(-)-6-(4-ammoniophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone (-)-tartrate-dichloromethane-methanol (1/1/1) (10), 4,5-dihydro-6-methyl-3(2H)-pyridazinone (11) have been determined as part of a study to determine the relationship between their cardiovascular properties and molecular structure and dimensions. For the two optically resolved chiral derivatives (9) and (10) the absolute configuration has been determined.