STUDIES OF THE NAPROXEN-BETA-CYCLODEXTRIN INCLUSION COMPLEX

被引：27
|
作者：
WANG, J [1 ]
WARNER, IM [1 ]
机构：
[1] LOUISIANA STATE UNIV,DEPT CHEM,BATON ROUGE,LA 70803
来源：
MICROCHEMICAL JOURNAL | 1993年 / 48卷 / 02期
关键词：
D O I：
10.1006/mchj.1993.1095
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The interaction of a nonsteroidal anti-inflammatory drug, naproxen, with β-CD has been studied by several analytical techniques, including 1-D and 2-D proton NMR. fluorescence spectroscopy, and FAB-MS. The negative ion FAB-MS confirmed the existence of a 1:1 inclusion complex of naproxen and β-CD. The formation constant of the complex was determined by use of 1-D NMR and fluorescence measurement. In the 1-D NMR data, a modified Benesi-Hildebrand procedure was employed to calculate the formation constant. In order to estimate the structure of the inclusion complex, 2-D rotating-frame Overhauser enhancement spectroscopy (ROESY) NMR was used to determine the spatial interaction in this dynamic system. A spatial configuration of the complex has been proposed based on these data. © 1993 Academic Press. All rights reserved.
引用
收藏
页码：229 / 239
页数：11
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