EFFECT OF SYNTHETIC ENANTIOMERIC CANNABINOIDS ON PLATELET-AGGREGATION

被引：2
作者：
NATHAN, I
AGAM, G
MECHOULAM, R
DVILANSKY, A
LIVINE, AA
机构：
[1] HEBREW UNIV JERUSALEM, FAC MED, JERUSALEM, ISRAEL
[2] BEN GURION UNIV NEGEV, DEPT HEMATOL, IL-84105 BEER SHEVA, ISRAEL
[3] BEN GURION UNIV NEGEV, DEPT LIFE SCI, IL-84105 BEER SHEVA, ISRAEL
来源：
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 1992年 / 70卷 / 10期
关键词：
ENANTIOMERIC CANNABINOIDS; PLATELET AGGREGATION;
D O I：
10.1139/y92-182
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of a synthetic pair of enantiomeric cannabinoids on platelet function was evaluated. The nonpsychotropic enantiomer, the 1,1-dimethylheptyl homolog of (+)-(3S,4S)-7-hydroxy-DELTA-6-tetrahydrocannabinol (HU-211), was found to be more active in inhibiting ADP-induced platelet aggregation than the highly psychotropic (-)-enantiomer (HU-210). The related (+)-(3R,4R) cannabinoid, HU-213, which lacks the 7-hydroxy moiety, exerted its inhibitory effect within a wider range of concentrations. The results indicate a differentiation between psychotropic activity and inhibition of platelet aggregation in the cannabinoid group of compounds.
引用
收藏
页码：1305 / 1308
页数：4
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