EFFECT OF SYNTHETIC ENANTIOMERIC CANNABINOIDS ON PLATELET-AGGREGATION

被引：2

作者：

NATHAN, I

AGAM, G

MECHOULAM, R

DVILANSKY, A

LIVINE, AA

机构：

[1] HEBREW UNIV JERUSALEM, FAC MED, JERUSALEM, ISRAEL

[2] BEN GURION UNIV NEGEV, DEPT HEMATOL, IL-84105 BEER SHEVA, ISRAEL

[3] BEN GURION UNIV NEGEV, DEPT LIFE SCI, IL-84105 BEER SHEVA, ISRAEL

来源：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 1992年 / 70卷 / 10期

关键词：

ENANTIOMERIC CANNABINOIDS; PLATELET AGGREGATION;

D O I：

10.1139/y92-182

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of a synthetic pair of enantiomeric cannabinoids on platelet function was evaluated. The nonpsychotropic enantiomer, the 1,1-dimethylheptyl homolog of (+)-(3S,4S)-7-hydroxy-DELTA-6-tetrahydrocannabinol (HU-211), was found to be more active in inhibiting ADP-induced platelet aggregation than the highly psychotropic (-)-enantiomer (HU-210). The related (+)-(3R,4R) cannabinoid, HU-213, which lacks the 7-hydroxy moiety, exerted its inhibitory effect within a wider range of concentrations. The results indicate a differentiation between psychotropic activity and inhibition of platelet aggregation in the cannabinoid group of compounds.

引用

收藏

页码：1305 / 1308

页数：4

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