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EPIDERMAL GROWTH-FACTOR RECEPTOR IN NORMAL OVARIES AND BENIGN OVARIAN-TUMORS
被引:6
|作者:
OWENS, OJ
[1
]
LEAKE, RE
[1
]
机构:
[1] UNIV GLASGOW,DEPT BIOCHEM,GLASGOW G12 8QQ,SCOTLAND
来源:
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
|
1992年
/
47卷
/
03期
关键词:
EGFR;
OVARY;
D O I:
10.1016/0028-2243(92)90156-S
中图分类号:
R71 [妇产科学];
学科分类号:
100211 ;
摘要:
Epidermal growth factor receptor (EGFR) was assayed in 52 women who had normal ovaries removed at hysterectomy and in 30 women with benign ovarian tumours. The histology of each ovary was recorded. A single point screen was performed on all samples and in positive cases a full Scatchard analysis. EGFR was present in 8 of 52 normal ovaries (15.4%) and 3 contained the high-affinity component while 5 had the low affinity component. In the benign ovarian tumour group 4 of 30 tumours (13.3%) had receptor present, one was high affinity and 3 were low affinity in type. We can conclude that EGFR is detectable only at low frequency in normal and benign ovarian tumours.
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页码:229 / 233
页数:5
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