MODULATION OF TRANSIENT TYPE-K CHANNEL CLONED FROM RAT-HEART

被引：15

作者：

OKADA, H ^{[1
]}

ISHII, K ^{[1
]}

NUNOKI, K ^{[1
]}

ABE, T ^{[1
]}

TAIRA, N ^{[1
]}

机构：

[1] TOHOKU UNIV,SCH MED,DEPT CLIN BIOL & HORMONAL REGULAT,SENDAI,MIYAGI 980,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 189卷 / 01期

关键词：

D O I：

10.1016/0006-291X(92)91576-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have cloned a transient type K channel from rat heart (RH10) and coexpressed a metabotropic glutamate receptor (mGluR5) to study the functional modulation of RH10 coupled to the phosphatidylinositol (PI) hydrolysis. Stimulation of mGluR5 suppressed peak amplitude of RH10 current and affected voltage dependence of activation and inactivation of the channel. © 1992.

引用

页码：430 / 436

页数：7

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