Nobel Prize in Chemistry-2018 Speeding Up Protein Evolution

被引:0
作者
Guptasarma, Purnananda [1 ,2 ,3 ]
机构
[1] Indian Inst Sci Educ & Res Mohali, Res & Dev, Mohali, Punjab, India
[2] IISER Mohali, Ctr Excellence Prot Sci Design & Engn, Mohali, Punjab, India
[3] Dept Biol Sci, Mohali, Punjab, India
来源
RESONANCE-JOURNAL OF SCIENCE EDUCATION | 2018年 / 23卷 / 12期
关键词
Phage-display; bacteriophage; error-prone PCR; mutation; phagemid; combinatorial library; biopanning; gene amplification; antibodies; protein engineering;
D O I
10.1007/s12045-018-0745-5
中图分类号
G40 [教育学];
学科分类号
040101 ; 120403 ;
摘要
The 2018 Nobel Prize for Chemistry rewards research on the use of bacteria and viruses to generate and screen highly diverse protein sequences for improved catalytic and ligand-binding function. One half of the Prize was awarded to Professor Frances Arnold of the California Institute of Technology (California, USA). The other half was awarded jointly to Professor George P Smith of the University of Missouri (Columbia, USA) and Professor Sir Gregory P Winter of the Medical Research Council's Laboratory of Molecular Biology (Cambridge, UK). The three winners have been amongst the tallest of stalwarts in combinatorial approaches to protein engineering. The 2018 Nobel Prize for Chemistry rewards research on the use of bacteria and viruses to generate and screen highly diverse protein sequences for improved catalytic and ligand-binding function. One half of the Prize was awarded to Professor Frances Arnold of the California Institute of Technology (California, USA). The other half was awarded jointly to Professor George P Smith of the University of Missouri (Columbia, USA) and Professor Sir Gregory P Winter of the Medical Research Council's Laboratory of Molecular Biology (Cambridge, UK). The three winners have been amongst the tallest of stalwarts in combinatorial approaches to protein engineering.
引用
收藏
页码:1343 / 1358
页数:16
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