SYNTHESIS AND PROPERTIES OF S,S-DIARYL NUCLEOSIDE PHOSPHORODITHIOATES IN OLIGONUCLEOTIDE SYNTHESIS

被引:39
作者
SEKINE, M [1 ]
HAMAOKI, K [1 ]
HATA, T [1 ]
机构
[1] TOKYO INST TECHNOL,DEPT LIFE CHEM,4259 NAGATSUTA,YOKOHAMA 227,JAPAN
关键词
D O I
10.1021/jo01327a077
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A new class of phosphorylating agents, S, S-diaryl phosphorodithioates, for the synthesis of oligothymidylates is described and properties of the bis(phenylthio) and bis(4-methoxyphenylthio) groups are also discussed. © 1979, American Chemical Society. All rights reserved.
引用
收藏
页码:2325 / 2326
页数:2
相关论文
共 39 条
[1]   NUCLEOSIDE 3'-PHOSPHOTRIESTERS AS KEY INTERMEDIATES FOR OLIGORIBONUCLEOTIDE SYNTHESIS .4. NEW METHOD FOR REMOVAL OF 2,2,2-TRICHLOROETHYL GROUP AND P-31-NMR AS A NEW TOOL FOR ANALYSIS OF DEBLOCKING OF INTERNUCLEOTIDE PHOSPHATE PROTECTING GROUPS [J].
ADAMIAK, RW ;
BIALA, E ;
GRZESKOWIAK, K ;
KIERZEK, R ;
KRASZEWSKI, A ;
MARKIEWICZ, WT ;
STAWINSKI, J ;
WIEWIOROWSKI, M .
NUCLEIC ACIDS RESEARCH, 1977, 4 (07) :2321-2329
[2]   CHEMICAL SYNTHESIS OF OLIGONUCLEOTIDES [J].
AMARNATH, V ;
BROOM, AD .
CHEMICAL REVIEWS, 1977, 77 (02) :183-217
[3]   DEOXY OLIGONUCLEOTIDE SYNTHESIS VIA TRIESTER METHOD [J].
CATLIN, JC ;
CRAMER, F .
JOURNAL OF ORGANIC CHEMISTRY, 1973, 38 (02) :245-250
[4]   NUCLEOSIDE S-ALKYL PHOSPHOROTHIOATES .2. PREPARATION AND CHEMICAL AND ENZYMATIC PROPERTIES [J].
COOK, AF ;
HOLMAN, MJ ;
NUSSBAUM, AL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1969, 91 (06) :1522-&
[5]  
CREA R, 1979, TETRAHEDRON LETT, P395
[6]  
CREA R, 1978, P NATL ACAD SCI US, P75
[7]  
ECKSTEIN F, 1967, ANGEW CHEM, V79, P939
[8]   BLOCKED STRUCTURE AT 5' TERMINUS OF MESSENGER-RNA FROM CYTOPLASMIC POLYHEDROSIS-VIRUS [J].
FURUICHI, Y ;
MIURA, KI .
NATURE, 1975, 253 (5490) :374-375
[9]   OLIGORIBONUCLEOTIDE SYNTHESIS .11. IMPROVED PREPARATION OF 2'-O-TETRAHYDROPYRANYL DERIVATIVES OF GUANOSINE AND ADENOSINE NECESSARY FOR INSERTION IN PHOSPHOTRIESTER SYNTHESIS [J].
GREGOIRE, RJ ;
NEILSON, T .
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1978, 56 (04) :487-490
[10]   CONVENIENT SYNTHESIS OF DINUCLEOTIDES BY OXIDATION-REDUCTION CONDENSATION USING NUCLEOSIDE 5'-PHOSPHORODIANILIDATES [J].
HASHIMOT.M ;
MUKAIYAM.T .
CHEMISTRY LETTERS, 1973, (05) :513-516