A CONTROLLED TRIAL OF CORTICOSTEROIDS TO PREVENT RESTENOSIS AFTER CORONARY ANGIOPLASTY

被引：238

作者：

PEPINE, CJ ^{[1
]}

HIRSHFELD, JW ^{[1
]}

MACDONALD, RG ^{[1
]}

HENDERSON, MA ^{[1
]}

BASS, TA ^{[1
]}

GOLDBERG, S ^{[1
]}

SAVAGE, MP ^{[1
]}

VETROVEC, G ^{[1
]}

COWLEY, M ^{[1
]}

TAUSSIG, AS ^{[1
]}

WHITWORTH, HB ^{[1
]}

MARGOLIS, JR ^{[1
]}

HILL, JA ^{[1
]}

BOVE, AA ^{[1
]}

JUGO, R ^{[1
]}

机构：

[1] VET AFFAIRS MED CTR, GAINESVILLE, FL USA

来源：

CIRCULATION | 1990年 / 81卷 / 06期

关键词：

D O I：

10.1161/01.CIR.81.6.1753

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A multicenter, double-blind, placebo-controlled trial was conducted to determine if cortico-steroids influence the development of restenosis after successful percutaneous transluminal coronary angioplasty (PTCA). Either placebo or 1.0 g methylprednisolone (steroid) was infused intravenously 2-24 hours before planned PTCA in 915 patients. The PTCA patient success rate was 87% (mean) in the eight centers. There were no differences in clinical or angiographie baseline variables between the two groups. End-point analysis (angiographic restenosis, death, recurrent ischemia necessitating early restudy, and coronary artery bypass graft surgery) showed that there was no significant difference comparing placebo- with steroid-treated patients. Angiographic restudy showed the lesion restenosis rate to be 39% (120 of 307 lesions) after placebo and 40% (117 of 291) after steroid treatment (p=NS). We conclude that pulse steroid pretreatment does not influence the overall restenosis rate after successful PTCA.

引用

页码：1753 / 1761

页数：9

共 41 条

[1] INTIMAL PROLIFERATION OF SMOOTH-MUSCLE CELLS AS AN EXPLANATION FOR RECURRENT CORONARY-ARTERY STENOSIS AFTER PERCUTANEOUS TRANS-LUMINAL CORONARY ANGIOPLASTY [J].