THE ABNORMAL INVITRO RESPONSE TO ASPIRIN OF PLATELETS FROM ASPIRIN-SENSITIVE ASTHMATICS IS INHIBITED AFTER INHALATION OF NEDOCROMIL SODIUM BUT NOT OF SODIUM CROMOGLYCATE

被引：13
作者：
MARQUETTE, CH
JOSEPH, M
TONNEL, AB
VORNG, H
LASSALLE, P
TSICOPOULOS, A
CAPRON, A
机构：
[1] Centre d'Immunologie et de Biologie Parasitaire(Unite mixte INSERM 167, CNRS 624), Institut Pasteur, Lille
来源：
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1990年 / 29卷 / 05期
关键词：
D O I：
10.1111/j.1365-2125.1990.tb03675.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. Blood platelets from patients with aspirin‐sensitive asthma (ASA) generated cytotoxic mediators in the presence of aspirin. This abnormal in vitro response to aspirin was abolished within 1 h after nedocromil sodium inhalation but not after sodium cromoglycate inhalation. 2. Platelets recovered this reactivity to aspirin by 12 hours after nedocromil sodium treatment of ASA‐patients. 3. The in vitro reactivity to aspirin of ASA platelets isolated before inhalation was inhibited in the presence of serum isolated 15 and 60 min after nedocromil sodium inhalation. 1990 The British Pharmacological Society
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页码：525 / 531
页数：7
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