EXTRA INTESTINAL MANIFESTATIONS AND COMPLICATIONS IN INFLAMMATORY BOWEL DISEASE

被引：0
|
作者：
Marineata, Anca [1 ]
Rezus, Elena [1 ]
Mihai, Catalina [2 ]
Prelipcean, Cristina Cijevschi [2 ]
机构：
[1] Univ Med & Pharm Grigore T Popa Iasi, Hosp Rehabil, Clin Rheumatol, Iasi, Romania
[2] Sf Spiridon Emergency Clin Hosp, Inst Gastroenterol & Hepatol, Iasi, Romania
来源：
MEDICAL-SURGICAL JOURNAL-REVISTA MEDICO-CHIRURGICALA | 2014年 / 118卷 / 02期
关键词：
INFLAMMATORY BOWEL DISEASE; ULCERATIVE COLITIS; CROHN'S DISEASE; EXTRAINTESTINAL MANIFESTATIONS;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), doesn't affect only the intestinal tract, but also involve other organs such as: eyes, skin, joints, liver and biliary tracts, kidneys, lungs, vascular system. It is difficult to differentiate the true extraintestinal manifestations from secondary extraintestinal complications. The pathogenetic autoimmune mechanisms include genetic susceptibility, antigenic display of autoantigen, aberrant self-recognition and immunopathogenetic autoantibodies against organ-specific cellular antigens shared by colon and extra-colonic organs. An important role is owned by microbes due to molecular mimicry. This paper reviews the frequency, clinical presentation and therapeutic implications of extraintestinal symptoms in inflammatory bowel diseases.
引用
收藏
页码：279 / 288
页数：10
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