INHIBITION OF OCHROMONAS RESPIRATION BY HYPOCHOLESTEREMIC COMPOUNDS AND ITS ANNULMENT BY UNSATURATED FATTY ACIDS

被引：6

作者：

AARONSON, S

ROZE, U

KEANE, M

ZAHALSKY, AC

机构：

[1] Biology Dept, Queens College, City Univ of New York, Flushing, New York

[2] Haskins Laboratories, New York, New York

来源：

JOURNAL OF PROTOZOOLOGY | 1969年 / 16卷 / 01期

关键词：

D O I：

10.1111/j.1550-7408.1969.tb02253.x

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

SYNOPSIS. Eleven of 14 hypocholesteremic drugs inhibited aerobic respiration of the phytoflagellate Ochromonas danica. Lecithin and unsaturated fatty acids annulled the inhibition of respiration by triparanol. Saturated fatty acids, squalene, cholesterol and a mixture of amino acids, purines, and water‐soluble vitamins were inactive. Unsaturated fatty acids only annul the triparanol inhibition if preincubated or added simultaneously with triparanol. Evidence is presented suggesting that triparanol and oleic acid form a complex or micelle; presumably in this form the triparanol no longer inhibits aerobic respiration. Copyright © 1969, Wiley Blackwell. All rights reserved

引用

页码：184 / &

共 12 条

[1] STUDY OF CELLULAR ACTION OF DRUGS WITH PROTOZOA .3. COMPARISON OF EFFECT OF SKF 525-A AND RELATED COMPOUNDS ON MULTIPLICATION OF OCHROMONAS DANICA [J].