Rationale and design of Long-term Outcomes and Vascular Evaluation after Successful Coarctation of the Aorta Treatment study

被引：4

作者：

Martins, Jose D. ^{[1
]}

Zachariah, Justin ^{[2
]}

Tierney, Elif Seda Selamet ^{[3
]}

Truong, Uyen ^{[4
]}

Morris, Shaine A. ^{[2
]}

Kutty, Shelby ^{[5
]}

de Ferranti, Sarah D. ^{[6
]}

Rhodes, Jonathan ^{[6
]}

Antonio, Marta ^{[1
]}

Guarino, Maria ^{[7
]}

Thomas, Boban ^{[8
]}

Oliveira, Diana ^{[9
]}

Gauvreau, Kimberlee ^{[6
]}

Jalles, Nuno ^{[8
]}

Geva, Tal ^{[6
]}

Carmo, Miguel ^{[7
]}

Prakash, Ashwin ^{[6
]}

机构：

[1] Ctr Hosp Lisboa Cent, Hosp Santa Marta, Dept Pediat Cardiol, Rua Santa Marta 50, P-1150024 Lisbon, Portugal

[2] Texas Childrens Hosp, Baylor Coll Med, Div Pediat Cardiol, Houston, TX 77030 USA

[3] Stanford Univ, Div Pediat Cardiol, Dept Pediat, Lucile Packard Childrens Hosp, Palo Alto, CA 94304 USA

[4] Childrens Hosp Colorado, Div Pediat Cardiol, Aurora, CO USA

[5] Univ Nebraska, Coll Med, Childrens Hosp & Med Ctr, Joint Div Pediat Cardiol, Omaha, NE 68198 USA

[6] Harvard Med Sch, Boston Childrens Hosp, Dept Cardiol, Boston, MA USA

[7] Nova Med Sch, CEDOC Chron Dis, Lisbon, Portugal

[8] Ressonancia Magnet SA, Caselas, Lisbon, Portugal

[9] Inst Super Tecn, Biomed Engn Dept, Lisbon, Portugal

来源：

ANNALS OF PEDIATRIC CARDIOLOGY | 2018年 / 11卷 / 03期

关键词：

Arterial stiffness; cardiac magnetic resonance imaging; coarctation of the aorta; long-term outcomes; pulse wave velocity; vascular function;

D O I：

10.4103/apc.APC_64_18

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background : Coarctation of the aorta (CoA) can be treated using surgery, balloon angioplasty, or stent implantation. Although short-term results are excellent with all three treatment modalities, long-term cardiovascular (CV) morbidity and mortality remain high, likely due to persistently abnormal vascular function. The effects of treatment modality on long-term vascular function remain uncharacterized. The goal of this study is to assess vascular function in this patient population for comparison among the treatment modalities. Methods : We will prospectively assess vascular Afunction in large and small arteries fusing multiple noninvasive modalities and compare the results among the three groups of CoA patients previously treated using surgery, balloon angioplasty, or stent implantation after frequency matching for confounding variables. A comprehensive vascular function assessment protocol has been created to be used in 7 centers. Our primary outcome is arterial stiffness measured by arterial tonometry. Inclusion and exclusion criteria have been carefully established after consideration of several potential confounders. Sample size has been calculated for the primary outcome variable. Conclusion : Treatment modalities for CoA may have distinct impact on large and small arterial vascular function. The results of this study will help identify the treatment modality that is associated with the most optimal level of vascular function, which, in the long term, may reduce CV risk.

引用

页码：282 / 296

页数：15