DNA-CARBOHYDRATE RECOGNITION - DESIGN AND SYNTHESIS OF AN 8-BASE SEQUENCE-SELECTIVE DNA-BINDING OLIGOSACCHARIDE

被引：0

作者：

NICOLAOU, KC ^{[1
]}

AJITO, K ^{[1
]}

KOMATSU, H ^{[1
]}

SMITH, BM ^{[1
]}

LI, TH ^{[1
]}

EGAN, MG ^{[1
]}

GOMEZPALOMA, L ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO, DEPT CHEM & BIOCHEM, LA JOLLA, CA 92093 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 05期

关键词：

DNA-BINDING MOLECULES; DNA CLEAVAGE; MOLECULAR RECOGNITION; OLIGOSACCHARIDES;

D O I：

10.1002/anie.199505761

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A decacyclic oligosaccharide was designed to dock into the minor groove of duplex DNA selectively at a TCCTXXAGGA sequence. Competition experiments with calicheamicin γ 1I revealed that the oligosaccharide inhibits DNA cleavage and exhibits high DNA binding affinity. Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：576 / 578

页数：3

共 10 条

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