CHARGE-TRANSFER CHROMATOGRAPHIC STUDY OF THE COMPLEX-FORMATION OF SOME ANTICANCER DRUGS WITH GAMMA-CYCLODEXTRIN

The interaction between 23 anticancer drugs and gamma-cyclodextrin (gamma-CD) was studied by reversed-phase charge-transfer thin-layer chromatography and the relative strength of interaction was calculated, gamma-CD formed inclusion complexes with 14 compounds, the complex always being more or less hydrophobic than the uncomplexed drug, The inclusion-forming capacity of a drug differed considerably depending on its chemical structure, The linear correlation between the hydrophobicity and the specific hydrophobic surface area of anticancer drugs indicated that they can be considered a homologous series of compounds, although their chemical structures are highly different. (C) 1995 Academic Press, Inc.