HIGH-RESOLUTION CYTOGENETIC MAPPING OF THE SHORT ARM OF CHROMOSOME-1 WITH NEWLY ISOLATED 411-COSMID MARKERS BY FLUORESCENCE IN-SITU HYBRIDIZATION - THE PRECISE ORDER OF 18 MARKERS ON 1P36.1 ON PROPHASE CHROMOSOMES AND STRETCHED DNAS

被引：30

作者：

ARIYAMA, T

INAZAWA, J

EZAKI, T

NAKAMURA, Y

HORII, A

ABE, T

机构：

[1] KYOTO PREFECTURAL UNIV MED,DEPT HYG,KAMIKYO KU,KYOTO 602,JAPAN

[2] JAPANESE FDN CANC RES,INST CANC,DEPT BIOCHEM,TOSHIMA KU,TOKYO 170,JAPAN

[3] KINKI UNIV,SCH MED,DEPT INTERNAL MED,SAYAMA,OSAKA 589,JAPAN

来源：

GENOMICS | 1995年 / 25卷 / 01期

基金：

日本科学技术振兴机构;

关键词：

D O I：

10.1016/0888-7543(95)80116-4

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A high-resolution cytogenetic map of the short arm of chromosome 1 with newly isolated 411 cosmid markers was constructed by fluorescence in situ hybridization (FISH). These markers were scattered throughout chromosome 1p, but they were preferentially concentrated on R-band dominant regions such as 1p36, 1p34, 1p32, 1p22, and 1p13. Among these markers, 197 were localized on chromosome band 1p36, a region frequently deleted in neuroblastoma. Of these, 18 were precisely ordered on 1p36.1 by multicolor FISH of prophase chromosomes and ''stretched'' DNAs as follows: 1pter-163-41-11-1-226-586-568-614-631-665-451-199-190-561-241-74-176-652-1cen. The high-density map of chromosome 1p constructed here can provide useful landmarks for constructing a contig map of the short arm of chromosome 1 with YACs and cosmid clones and will expedite the identification of breakpoints and/or tumor suppressor gene(s) associated with several types of malignant tumors that frequently exhibit chromosomal aberrations or deletions of chromosome 1p. (C) 1995 Academic Press, Inc.

引用

页码：114 / 123

页数：10

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